For the determination of Itraconazole in pure formulations and its pharmaceutical formulations, a simple UV-spectrophotometric method was developed. Itraconazole exhibited maximum absorption at 262nm in ethanol and obeyed linearity in the concentration range of 4-14 μg/ml. The method proposed was validated statistically. With good accuracy, all the proposed methods are simple, selective, reproducible, sensitive and precise. Some of the methods were proved to be superior to most of the reported methods. Many of these suggested prediction methods for chosen drugs, such as Itraconazole, have been successfully implemented either in bulk or in prescription formulations. The suggested methods can be used in bulk and prescription dosage formulations as alternative methods to the recorded ones for the routine determination of selected drugs in the sample.