A simple, precise, rapid and accurate RP- HPLC method was developed for the estimation of Pomalidomide (PML) in capsule dosage forms. A Kinetex phenyl Hexyl C18Thermo scientific 250 x 4.6 mm, 5 µm column and the mobile phase, consisting of 0.1 M KH2PO4 in water adjusting the pH- 2.5 with O-Phosphoric Acid: Methanol in ratio of 30:70 v/v was used for method development. The flow rate was 1 ml/min and the effluents were monitored at 221 nm. The retention time was found to be 4.7 min for PML. The detector response was linear in the concentration of 15.47- 45.42 µg/mL for PML. The respective linear regression equation being Y = 11771 x - 92623 for PML. The Limit of Detection (LOD) is 0.079& The Limit of Quantification (LOQ) is 0.235 for PML respectively. The % assay of PML was found out to be 100.9%. The method was validated by determining its accuracy, precision and system suitability. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate, which is useful for the routine determination of PML in bulk drug and in its pharmaceutical dosageforms.