Fast dissolving tablets (FDTs) are novel drug delivery type of tablets that dissipate or disintegrate in saliva within a few seconds without water. Diclofenac Sodium was used as a main drug in this formulation. Diclofenac Sodium is widely prescribed analgesic drug and used to relieve pain, inflammation and joint stiffness. All the formulations were prepared by using direct compression method, which is a traditional method of preparation. Different parameters like pre and post-compressional parameters were tested and final formula was selected based on in-vitro disintegration time and in-vitro dissolution profile. Where, all the formulations were dissipated < 40 seconds and F6 formulations was showing 100% release at 30 minute and faster, compared to the marketed formulation and the formulation was found to be stable.