Aim: The present study was conducted to evaluate the proximate and elemental analysis of two different medicinal plants namely Cassis alata and Spermacoce latifolia which are frequently grown in Bangladesh. Methodology: Macro (Na, K, Ca, Mg), micro (Al, Fe, Cu, Mn, Zn, Ni, Cr) and heavy metal (Pb, Cd) elements were determined quantitatively in the leaves of Cassia alata and in the root and aerial parts of Spermacoce latifolia by using flame photometer and atomic absorption spectroscopy (AAS). Results: The elemental contents of the plants were evaluated in considerable amounts (Na: 611.87-1223.88 ppm, K: 5532.37-8344.77 ppm, Al: 1349-9798.52 ppm, Ca: 13131.45-18591.65 ppm, Mg: 2165.71-5068.38 ppm, Fe: 924.93-1192.16 ppm, Cu: 8.36-12.89 ppm, Mn: 68.58-221.07 ppm, Zn: 116.96-323.60 ppm, Ni: 3.88-14.29 ppm, Cr: 1.59-4.56 ppm, Pb: 14.28-27.82 ppm and Cd: 0.0827-0.7313 ppm. Conclusion: The mineral analysis showed that the macro (Na, K, Ca, Mg) elements are present in higher amount than the micro (Al, Fe, Cu, Mn, Zn, Ni, Cr) elements which indicate the effectiveness of these plants in treating various ailments. And the concentrations of the heavy metals (Pb, Cd) are in very trace amount which shows that these plants are safe for medicinal uses.