This study was conducted to assess its pharmacological proprieties. The studies were performed using Wistar rats divided into groups. Treatments were administered via oral route and at single dose for seven days, followed by injection of a hepatotoxic substance (DNPH) or cardiotoxic substance (doxorubicin). Blood samples were collected for the carrying out of biochemical analyses of markers of heart, markers of liver and makers oxidative stress. Regarding anti-inflammatory activity, after administration of treatments via oral route, the volume of the legs of the animals was measured. The results helped to highlight the hepatoprotective, cardioprotective and antioxidant properties of Hibiscus sabdariffa. The assessment of anti-inflammatory activity has led to two main results. Induction of inflammation by carrageenan and anti-inflammatory property of Hibiscus sabdariffa. These results confirm and reinforce the position of Hibiscus sabdariffa as a medicinal plant with several potential therapeutic and protective for the heart and liver.