Allodynia and hyperalgesia comprise the main and frequent symptoms suffered by patients with neuropathic pain, which responds poorly to therapy. Mimosa pudica (Thottavadi) found in different parts of India has been extensively used as medications for various diseases including CNS disorders. The present study examined the antineuropathic effect of whole plant of Mimosa pudica on vincristine induced neuropathic pain with improved efficacy and safety. Neuropathic pain was induced by the administration of vincristine sulphate injection (1mg ml^-1, i.p) for once per day for 10 days in 5 days on 2 days off cycle. Pain behaviour was assessed at different days, i.e., 0,7,14 and 21 days. Sciatic nerve total calcium, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), nitric oxide (NO), lipid peroxidation (LPO) and total calcium were also estimated after the 21^st day of study. Pregbalin (10mg/kg, p.o.) and hydroethanolic extract of Mimosa pudica (HEMP) (200 & 400 mg/kg, p.o.) were administered for 7 consecutive days after the induction of neuropathic pain. The extract produced significant (p<0.01) and dose dependent inhibition of vincristine- induced neuropathic pain manifestations in terms of thermal hyperalgesia, cold allodynia, antioxidant levels, total calcium and protein. The hydroethanolic extract of Mimosa pudica at 200 and 400 mg/kg dose levels significantly attenuated vincristine induced neuropathy which may be due to its multiple actions including anti-nociceptive, anti-inflammatory, calcium inhibitory and anti- oxidant effect.