Weeds are the plants that invade native ecosystems and are undesirable for the survival of indigenous flora and fauna. Typically these are the plants that grow aggressively and multiply very quickly without any natural controls. These plants display adverse effects through contact or ingestion. One such weed called Lantana camara has become one of the most invasive weeds and is known to outgrow native vegetation. Despite the measures taken to eradicate this weed, it is still growing in wide range of habitats as it can grow in extreme harsh conditions also. It is desirable to find some alternative use of this weed as it is very difficult to eliminate. Therefore the present investigation deals with evaluation of this potentially toxic weed as a medicinal plant. With this view in mind, the present study was carried out to evaluate the anti-quorum sensing potential of this weed. Different solvent extracts of the plant were prepared with Soxhlet apparatus and were tested for anti-swarming potential against Proteus mirabilis and pigment inhibition in Serratia marcescens. P.ether (3.33+0.57), Chloroform (3.66+1.15), and methanol (4+1) extracts of L. camara showed maximum inhibition in the swarming pattern of Proteus mirabilis. Reduction in the pigment production without inhibiting the bacterial growth in Serratia marcescens was observed in the presence of ethyl acetate (28±0.1) and methanol (21±0.1) extract. Results of the study indicate that despite being a toxic weed Lantana camara can be alternatively utilized as potent quorum sensing inhibitory plant and can be put for evaluation for diversified applications.