A simple, rapid and sensitive UV Spectroscopy method was developed and validated for estimation of Atomoxetine HCl in tablet dosage form. The spectrophotometric method was carried out at maximum absorbance of 271nm for Atomoxetine HCl using acetonitrile as a solvent. Calibration curve was plotted with a range of 20-140µg/ml for Atomoxetine HCl and correlation was found to be 0.999.The limit od detection and limit of Quantification were found to 3.5µg/ml, 10.62µg/ml .The percentage values for all the parameters was found to be not more than 2. The developed method can be used for routine determination of Atomoxetine HCl in pharmaceutical dosage form and method is developed and validated as per ICH guidelines.