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VOL. 2, ISSUE 4 (2017)
Development and in vitro evaluation of ciprofloxacin gastric floating tablets
Authors
Rajesh Akki, M Gayatri Ramya, M Hyma vathi
Abstract
Objective: The aim of present investigation was to formulate, evaluate and optimize process of gastroretentive tablets of ciprofloxacin hydrochloride. Ciprofloxacin hydrochloride has a short elimination half-life of about 4 hrs and oral bioavailability of about 70%. Ciprofloxacin hydrochloride has a narrow absorption window and is mainly absorbed in the proximal areas of GIT. Development of gastroretentive dosage form can be advantageous, that can provide prolong gastric retention and increase efficacy of the dosage form.
Methods: Gastroretentive floating tablets (GRFT) were prepared by using a hydrophilic polymer polyethylene oxide of different grades such as PEO WSR N-12 K, PEO 18 NF and olibanum gum as release retarding polymers and sodium bicarbonate as gas generating agent. The GRFT were compressed by wet granulation method.
Results: The tablets were evaluated for physicochemical properties, in vitro buoyancy, swelling studies, in vitro dissolution studies and release mechanism studies. From the dissolution and buoyancy studies, F 4 was selected as an optimized formulation.
Conclusion: Optimized formulation (F 4) when characterized with FTIR studies showed no interactions between drug and polymer. The gastroretentive floating drug delivery is a promising approach to achieve in vitro buoyancy by using hydrophilic polymers of polyethylene oxide grades such as PEO WSR N 12 K, PEO 18 NF
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Pages:71-77
How to cite this article:
Rajesh Akki, M Gayatri Ramya, M Hyma vathi "Development and <em>in vitro </em>evaluation of ciprofloxacin gastric floating tablets". International Journal of Research in Pharmacy and
Pharmaceutical Sciences, Vol 2, Issue 4, 2017, Pages 71-77
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