Method: The rats were divided into five experimental groups viz., Normal control, ISO-treated (Disease control), Propranolol (10 mg/kg + ISO), Chonemorpha fragrans (100 mg/kg +ISO) and Chonemorpha fragrans (200 mg/kg + ISO). Myocardial infarction in rats was induced by the administration of isoproterenol at a dose of 85mg/kg i.p., the rats in group IV and group V were pretreated with ethanolic extract of Chonemorpha fragrans in the dose of 100mg/kg b.w. and 200mg/kg b.w. through oral route. Cardiac marker enzymes, lipid profile and antioxidant enzymes as biomarker of cardiotoxicity were determined in experimental animals.

Result: Animals treated with root extract of Chonemorpha fragrans showed significant decrease in Triglycerides, AST, ALP, antioxidant enzymes viz., superoxide dismutase, LPO and increase in HDL-Cholesterol.

Conclusion: The results of the study demonstrate that Chonemorpha fragrans strongly protected the myocardium against isoproterenol-induced infarction and suggest that the cardioprotective effects could be related to antioxidant activities.