Epilepsy is one of the most widespread neurological disorders in the world. To elucidate the consequences of convulsion, we examined biochemically and electrophysiologically the brains of mice that had sustained two complete tonic clonic convulsions after administration of pentylenetetrazole (PTZ 75mg/kg intraperitoneally, i.p) Khameera Marwarid Abdul Hameed reduced the latency time. The high dose of Khameera Marwarid Abdul Hameed 500mg/kg induced the seizures frequency, but at low dose 50mg/kg reduce the seizure frequency. PTZ was given 45mg/kg on 1, 3, 5 and on 8 day, on 10^th day 75mg/kg (I.P) and after that observe the seizure activity. At high dose 2mg/kg (Piperine) the seizure frequency was high, but at low dose 1mg/kg (Piperine) the seizure frequency was low. The sodium valproate 300mg/kg (p.o) was used as a standard drug. The test drugs was administered and compared with standard drug. Control mice were injected saline(0.9%) and PTZ 75mg/kg, after that observe the seizure activity for last 30 minutes, generally observe the tonic clonic convulsion at high dose of 75mg/kg, but at low dose 45mg/kg 50% animal shows the convulsion(tonic convulsion).The combined formulation (KAH(50 mg/kg + Piperine 1 mg/kg) was found to be more effective and worked as an antiepileptic drugs when compared to standard group (sodium valproate 300mg/kg). These result show that Khameera Marwarid Abdul Hameed at low dose(50mg/kg) was act with varied mechanism of action and it is clinically useful in the treatment of epilepsy and show less side effect as compared to other antiepileptic drugs.