Background: Resveratrol is a member of the stilbene family emerged as a leading candidate for improving health span through potentially slowing the aging process and preventing chronic diseases. The present investigation deals preformulation, solubility assessment and screening of oils, surfactants and cosurfactants combinations for resveratrol formulation design. Preformulation data is helpful to initiate formulation development of resveratrol molecule. In this research, preformulation studies for resveratrol have been performed to determine factors which influence solubility and stability which, in turn, can be used to assist future formulation development of resveratrol. Method: Preformulation and characterization is an important step in the rational formulation of an active pharmaceutical ingredient (API). Solubility assessment and screening of oils, surfactants and cosurfactants combinations for resveratrol was done to enhance its solubility which in turn can enhance bioavailability. Result: Optimized self-emulsion formulation composed of Labrafil M 2125 (4.98 w/w), Kolliphor ELP (52.18 w/w), Ethanol (26.01 w/w). Mean droplet size in selected nanocarrier found to be 83.29 nm The in vitro release was found to be higher in formulation containing combinations of these components as self-emulsion formulation in comparison to pure resveratrol. Conclusion: Results obtained indicated that HLB value, oil solubility, hydrophobic chain length, greatly influence microemulsion and nan emulsion regions. The study demonstrated that solid lipid nanoparticle, self-emulsifying drug delivery system, liposome formulation will be the promising strategies to enhance solubility, stability and in vitro release of resveratrol.