Research on the combined effect of centella asiatica extract and papaya latex. The healing of burns on white male mice. Examination burn healing done by measuring the diameter of the burn until the wound completely healed. Dose combination centella asiatica extract and papaya latex given row is (1%: 1%); (1.5%: 0.5%); (0.5%: 1.5%) on a daily basis. Measuring the diameter of burns conducted up to the 10th day. The results showed that the dosing combination centella asiatica extract and papaya latex can accelerate the healing of burns significantly (P <0.05). Giving combination centella asiatica extract and papaya latex showed a faster recovery time and better than the singular respectively. Healing time of burns optimal dosing is achieved by a combination of centella asiatica extract 1% and 1% papaya latex. Measurement of the percentage of healing from the first day until the 6th day, showed a significant effect (P <0.05).